Robert C Murphy Selected Research

Eicosanoids

1/2019	Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid.
6/2016	Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid.
1/2016	Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
1/2016	Phospholipid Ozonation Products Activate the 5-Lipoxygenase Pathway in Macrophages.
1/2016	Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection.
1/2015	The role of PGE2 in intestinal inflammation and tumorigenesis.
10/2014	Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells.
1/2013	Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation.
1/2013	Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.
6/2012	The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock.

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Robert C Murphy Research Topics

Disease

26	Inflammation (Inflammations) 10/2022 - 05/2004
10	Neoplasms (Cancer) 01/2020 - 01/2005
9	Heart Failure 01/2014 - 06/2005
7	Infections 10/2022 - 04/2010
5	Pain (Aches) 01/2019 - 05/2010
5	Prostatic Neoplasms (Prostate Cancer) 01/2016 - 06/2011
5	Atherosclerosis 06/2015 - 07/2009
4	Brain Injuries (Brain Injury) 06/2014 - 11/2009
3	Lung Diseases (Lung Disease) 01/2017 - 12/2008
3	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2014 - 11/2009
3	Heart Diseases (Heart Disease) 01/2014 - 04/2008
3	Peritonitis 07/2009 - 11/2008
3	Necrosis 01/2006 - 07/2002
2	COVID-19 01/2022 - 01/2020
2	Thrombosis (Thrombus) 01/2022 - 05/2014
2	Fever (Fevers) 01/2019 - 06/2016
2	Melanoma (Melanoma, Malignant) 04/2016 - 12/2014
2	Lung Neoplasms (Lung Cancer) 01/2016 - 01/2013
2	Neoplasm Metastasis (Metastasis) 01/2016 - 02/2014
2	Atherosclerotic Plaque (Atheroma) 01/2016 - 11/2011
2	Cardiovascular Diseases (Cardiovascular Disease) 04/2015 - 05/2014
2	Respiratory Syncytial Virus Infections 03/2015 - 08/2013
2	Carcinogenesis 01/2015 - 01/2005
2	Ischemia 12/2014 - 09/2008
2	Cognitive Dysfunction 06/2014 - 08/2012
2	Brain Edema (Cerebral Edema) 06/2014 - 05/2004
2	Insulin Resistance 05/2014 - 01/2013
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2014 - 07/2007
2	Disease Progression 01/2014 - 09/2008
2	Cardiomegaly (Heart Hypertrophy) 01/2014 - 09/2008
2	Neuroinflammatory Diseases 01/2014 - 05/2010
2	Hemorrhage 04/2013 - 03/2010
2	Scott Syndrome 04/2013 - 03/2010
2	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2012 - 03/2010
2	Edema (Dropsy) 06/2011 - 05/2004
2	Sepsis (Septicemia) 09/2010 - 12/2004
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021

Drug/Important Bio-Agent (IBA)

21	LipidsIBA 01/2022 - 01/2006
15	EicosanoidsIBA 01/2019 - 01/2005
11	LeukotrienesIBA 01/2016 - 05/2004
9	Proteins (Proteins, Gene)FDA Link 10/2022 - 02/2004
7	Phospholipids (Phosphatides)FDA LinkGeneric 01/2018 - 07/2002
7	Arachidonic Acid (Vitamin F)IBA 01/2016 - 01/2005
6	Cardiolipins (Cardiolipin)IBA 06/2012 - 06/2005
5	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2016 - 07/2009
5	EnzymesIBA 01/2016 - 01/2005
5	ProstaglandinsIBA 01/2016 - 01/2004
5	Dinoprostone (PGE2)FDA Link 06/2015 - 01/2005
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 11/2011
4	Linoleic Acid (Linoleate)IBA 01/2014 - 09/2008
4	Docosahexaenoic AcidsIBA 01/2014 - 09/2008
4	Leukotriene B4IBA 01/2013 - 11/2010
4	LigandsIBA 04/2011 - 05/2003
3	Biological ProductsIBA 10/2022 - 08/2007
3	Fatty Acids (Saturated Fatty Acids)IBA 10/2022 - 09/2008
3	PhosphatidylserinesIBA 01/2022 - 04/2011
3	CytokinesIBA 11/2018 - 01/2016
3	Leukotriene C4IBA 01/2018 - 06/2012
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2016 - 01/2013
3	Choline (Choline Chloride)IBA 01/2016 - 06/2011
3	MK-886IBA 06/2014 - 11/2009
3	ZymosanIBA 07/2009 - 11/2008
2	phosphatidylethanolamineIBA 01/2022 - 01/2020
2	CeramidesIBA 01/2021 - 06/2011
2	Platelet Activating FactorIBA 11/2018 - 12/2014
2	Interleukin-6 (Interleukin 6)IBA 11/2018 - 01/2016
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2018 - 08/2012
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 04/2016 - 12/2014
2	Phospholipases A2 (Phospholipase A2)IBA 01/2016 - 01/2013
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 06/2015 - 04/2010
2	Interleukin-8 (Interleukin 8)IBA 06/2015 - 08/2013
2	CollagenIBA 06/2015 - 01/2004
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2015 - 01/2014
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 04/2015 - 12/2009
2	AntioxidantsIBA 12/2014 - 03/2012
2	Retinaldehyde (Retinal)IBA 03/2014 - 03/2010
2	Pulmonary Surfactants (Pulmonary Surfactant)IBA 08/2013 - 01/2006
2	Thrombin FDA Link 04/2013 - 03/2010
2	Triglycerides (Triacylglycerol)IBA 01/2013 - 04/2012
2	oxidized low density lipoproteinIBA 08/2012 - 11/2011
2	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 08/2012 - 04/2012
2	lardIBA 06/2012 - 09/2008
2	Safflower Oil FDA Link 06/2012 - 09/2008
2	salicylhydroxamic acid (SHAM)IBA 06/2012 - 12/2009
2	cysteinyl-leukotrieneIBA 03/2012 - 11/2009
2	Leukotriene A4IBA 11/2010 - 02/2004
2	Eicosapentaenoic AcidIBA 12/2009 - 09/2009
2	Fish OilsIBA 12/2009 - 09/2009
2	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2008 - 03/2002
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 04/2008 - 07/2007
1	Carnitine (L-Carnitine)FDA LinkGeneric 10/2022
1	TransferasesIBA 10/2022
1	OxylipinsIBA 10/2022
1	Povidone-Iodine (Betadine)FDA LinkGeneric 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	MouthwashesIBA 01/2022
1	Cetylpyridinium (Cetylpyridinium Chloride)IBA 01/2022
1	Carboxy-LyasesIBA 01/2020

Therapy/Procedure

3	Therapeutics 01/2016 - 04/2013
2	Drug Therapy (Chemotherapy) 12/2014 - 11/2014